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Solutes

One Stop Pharmacokinetic Program:

  • Physiologically Based Pharmacokinetics Modeling

  • Deconvolution

  • Many novel features
  • Applicable to most drugs
  • Easy to use
  • Detailed graphical output

New revised version:  PKQuest_Java3.2    -  August, 2011:
Added features:  1) Deconvolution;  2) Non-compartmental Pharmcokinetics;  3)  Direct fit to individual tissues.

 

  Free Java Based Interactive Version.
  Complete PBPK software package.
   Features:

        Intuitive and versatile interactive interface.
        Uses pre-programmed optimized human parameter set
        Allows time dependent PBPK parameters
        Non-linear parameter optimization
        Unique solution for oral "first pass metabolism" of non-linear solutes
        Volatile solutes and alveolar perfusion/ventilation heterogeneity
        Input and output of Excel spreadsheet data
        Antecubital vein sampling
              ... and much more

     Download PKQuest_Java
     

Novel features and applications are illustrated in a series of  publications evaluating deconvolution techniques and describing the human pharmacokinetics of:               
  •  D2O
  •  Propranolol
  •  Ethanol
  •  Inulin
  •  Dicloxacillin
  •  Ceftriaxone
  •  Toluene
  •  Nitrous Oxide
  •  Enflurane
  •  Halothane
  •  Methoxyflurane
  •  Toluene 
  •  Propofol
  •  And Many More - See Publications   
 
   
 
   

2002 David Levitt  
Email: levit001@umn.edu last updated: 09/12/2011